Cnad 2007
نویسندگان
چکیده
Corticotropin-releasing factor (CRF) immunoreactivity in the central nucleus of the amygdala (CeA). Ethanol dependence was induced by intermittent exposure to ethanol vapors for 4 weeks, and animals were sacrificed after 2 hours of withdrawal. Brains were removed, and CRF expression was measured in the CeA by using immunohistochemical techniques. The data are expressed as the relative density of CRF immunoreactivity (n = 3 animals). A, CRF immunoreactivity was measured from 5 serial sections throughout the CeA. From bregma, these sections were −2.12 mm, −2.30 mm, −2.56 mm, −2.80 mm, and −3.14 mm. CRF immunoreactivity was significantly decreased in the CeA at bregma −2.80 and −3.14 in withdrawn, dependent animals relative to control animals. B, Representative micrographs (20x) from the CeA (bregma −2.80 mm) show CRF staining within this brain region. * P < .01 compared with nondependent animals. Bar graph by Cindy Funk, Ph.D., research associate; immunohistochemical brain photo, by Elena Crawford, scientific associate. Work done in the laboratory of G.F. Koob, Ph.D., professor. Reprinted with permission from Funk, C.K., O'Dell L.E., Crawford, E.F., Koob, G.F. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. J. Neurosci. 26:11324, 2006. Copyright 2006 by the Society for Neuroscience. Nondependent Dependent
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